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Transplant Research Center

 

Address:

Namazi Hospital, Transplant Research Center

 Tel: +98 711 6276211Fax: +98 711 6276211e-mail: transrsh@sums.ac.ir

 

Shiraz Transplant Research Center (STRC) began its activities in 2001 with the aim of research in different fields of transplantation, especially because:

·  Shiraz University of Medical Sciences is one of the active centers of transplantation in kidney.

·  Liver transplantation is exclusively done in Shiraz.

· There is an active team of bone marrow transplantation in hematology department.

· Corneal transplant is done in ophthalmology department.

Objectives STRC was developed to carry out the following goals:

§ Carry out research in different aspects of transplantation , to apply new tests for transplanted patients to create better life quality for them.

§ Gathering and registering exact and detail information about all of our transplanted patients, to have complete data from these patients such as viral markers and so on.

§ Training manpower for carrying out research and applying activities in the field of transplantation

Table 5-3: Academic Staff Strength

Research area

Rank

Academic Staff

Pathology

MD Professor

S.Z. Tabei

Surgery

MD , Associate Professor

S.A. Malekhosseini

Pathology

MD , Associate Professor

B. Geramizadeh

Hematology Department

MD , Associate Professor

M. Zakerinia

Ophthalmology

MD Assistant Professor

H.R Jahadi Hosseini

Physiology

PhD Assistant Professor

M. Varedi

Pathology

MD , Assistant Professor

N.Azarpira

Medical Genetics

PhD , Student

M.Ayatollahi

Molecular Biology

MS

M.Aghdaei

Virology

PhD, Associate Professor

A.Behzad-Behbahani

Virology

PhD , Assistant Professor

R.Yaghoobi

 

Current Research

§ Establishment of amniotic membrane tissue bank

§ Evaluation of amplified variable number of tandem repeats ( VNTR) in the detection of chimerism following bone marrow transplantion

§ Isolation , growth and function of neonatal and adult rat islet cells

§ Apoptosis and expression of Fas , Fas L , GMP 17 in cytotoxic T lymphocytes in renal transplant recipients and relation with acute rejection

§ Determination of humancytomegalovirus ( gN ) genotypes polymorphism in organ transplant patients

§ Construction of tissue-engineered heart valves

§ Autologous transplantation of tissue engineered urothelium into demucosalized ileal segments for experimental bladder wall reconstruction

§ Evaluation of the correlation between cystatin level & Cr,BUN & Apoptotic markers : GMP – 17 , fas , fas ligand , CD8+ T cells

§ Evaluation of the value of serum cystatin C as a surrogate marker for creatinine in liver & renal transplant patients

§ Effects of quercetin on the expression and adhesion of a2 B1 – integrin in kidney fibroblast from cyclosporine A-induced nephrotoxicity in rats

§ The effect of cytokine gene Polymorphism INFδ , TNFα , IL10 in acute rejection following renal transplantation

§ Therapeutic use of human adult bone marrow stem cell for neurigical disorders such as multiple sclerosis

§ Evaluation of effects of heparanase administration on skin autograft and allograft healin in rat

§ Comparison between IHC findings of HBSAg and HBCAg with grade and stage in HBV

§ Correlation of the hum oral immunologic factors with infectious complication after organ transplantation

§ Evaluation of the role of HBV virus genotype on inflammation , fibrosis and surface and core antigen level in liver biopsies of hepatitis B patients

§ Establishment of transplant sample bank

§ The effect of IL-10 promoter gene polymorphism with an occurrence of graft versus host disease in bone marrow transplant patients in Nemazi hospital

§ Isolation , characterization and deposition of human endothelial cells

 
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